CARFILZOMIB, LENALIDOMIDE AND DEXAMETHASONE IN RELAPSED/REFRACTORY MULTIPLE MYELOMA PATIENTS: THE REAL-LIFE EXPERIENCE

Carfilzomib, lenalidomide and dexamethasone in relapsed/refractory multiple myeloma patients: the real-life experience

Background.Carfilzomib, lenalidomide, and dexamethasone (KRd) have been approved for the treatment of relapsed and refractory multiple myeloma (RRMM) based on ASPIRE clinical trial.Aim.Analysis of efficacy and safety of KRd in routine clinical practice.Materials and methods.The prospective analysis included patients with MM who received at least on

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Modeling environmental variability and network formation among pastoral nomadic households: Implications for the rise of the Mongol Empire.

We use agent-based computer simulation to test the effect of environmental conditions (available biomass/carrying capacity and environmental risk) on the development of wealth inequality and patron-client herding networks in nomadic pastoral economies.Our results show that 1) wealth inequality reaches very high levels when carrying capacity is high

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Floral organ MADS-box genes in Cercidiphyllum japonicum (Cercidiphyllaceae): Implications for systematic evolution and bracts definition.

The dioecious relic Cercidiphyllum japonicum is one of two species of the sole genus weight pin Cercidiphyllum, with a tight inflorescence lacking an apparent perianth structure.In addition, its systematic place has been much debated and, so far researches have mainly focused on its morphology and chloroplast genes.In our investigation, we identifi

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